The Science

Science That Can Revolutionize Human Health

Nutrient Partitioning

In 1996, Dr. Wayne Lautt and his colleagues first discovered a hormone they called hepatic insulinsensitizing substance (HISS).

Through their ongoing research, Dr. Lautt and his SciMar team have determined that it is important for HISS and the hormone insulin to be in healthy balance. HISS, when adequately produced, stimulates the body’s ability to partition glucose into muscle. When the liver does not adequately produce HISS, the pancreas produces additional insulin, which causes nutrient energy to be partitioned into fat.

Their work is keenly focused on this process of “Nutrient Partitioning” and on developing a series of “NuPa” products to measure metabolic health and to stimulate the production of HISS. One product—“NuPa Test”—invites people to drink a specially formulated shake. Their body’s ability to produce HISS and thereby properly partition nutrients can then be measured. When HISS production is shown to be inadequate, appropriate interventions can be considered.

Science has proven so far that this essential secretion of HISS is hindered by stress, the lack of exercise, the consumption of sugar, and other lifestyle factors. Therefore, the goal of SciMar’s work is to determine ways for the body to always produce the right amount of HISS and to keep HISS and insulin in a healthy balance. The science suggests that when the right amount of HISS is present nutrient partitioning is in balance, thereby helping people to avoid type 2 diabetes. For those already living with type 2 diabetes, managing HISS effectively is expected to help people avoid the disease’s worst impacts.

Once broadly adopted, HISS and nutrient partitioning will change the paradigm in diabetes prevention and treatment. Through its leadership of the WTN, SciMar will learn how different lifestyle interventions affect the production of HISS, and how its NuPa product pipeline can revolutionize the prevention and treatment of type 2 diabetes for all time.

The collaborative efforts of the WTN will help conclusively demonstrate the validity and importance of this remarkable science.

I became a scientist because I wanted to make a positive difference in the world. This is a culmination of my life’s work that I know will change the course of human health.
- Dr. Wayne Lautt

Founder, Chief Scientific Officer, SciMar Ltd. Professor Emeritus, Department of Pharmacology and Therapeutics, University of Manitoba

Diabetes Data
Here is the problem we are working to solve

In 2014, 387 million People around the world were living with type 2 diabetes7

In 2015, 3.4 million Canadians (9.3% of the population) were living with diabetes. That number is expected to grow to 5 million (12.1%) by 2025.1

Diabetes was responsible for 5.1 million deaths around the world in 20135

Without a major change in prevention medicine, 50% of all Canadian youth and 80% of all Indigenous youth will develop type 2 diabetes in their lifetimes3

In 2015, 5.7 million Canadians were pre-diabetic that number is expected to be 6.4 million by 20252

Over five million Canadian adults have obesity, according to the 2014 Canadian Community Health Survey, and 10% of premature deaths among Canadians (20-64) are directly attributable to obesity6

In Canada, people with type 2 diabetes represent 50% of all people on kidney dialysis4

1Diabetes Canada 2Diabetes Canada
3Canadian Medical Association Journal 4Diabetes Canada
5International Diabetes Federation (2014) 6Obesity Canada
7International Diabetes Federation (2014)

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